A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2+) channels

Ca(v)3 / T-type Ca(2+) channels are dynamically regulated by intracellular Ca(2+) ions, which inhibit Ca(v)3 availability. Here, we demonstrate that this inhibition becomes irreversible in the presence of non-hydrolysable ATP analogs, resulting in a strong hyperpolarizing shift in the steady-state i...

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Detalles Bibliográficos
Autores principales: Chemin, Jean, Stamenic, Tamara Timic, Cazade, Magalie, Llinares, Jodie, Blesneac, Iulia, Todorovic, Slobodan M., Lory, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821770/
https://www.ncbi.nlm.nih.gov/pubmed/31666636
http://dx.doi.org/10.1038/s41598-019-52194-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821770/
https://www.ncbi.nlm.nih.gov/pubmed/31666636
http://dx.doi.org/10.1038/s41598-019-52194-6

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