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Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

Organoids derived from human pluripotent stem cells are interesting models to study mechanisms of morphogenesis and promising platforms for disease modeling and drug screening. However, they mostly remain incomplete as they lack stroma, tissue resident immune cells and in particular vasculature, whi...

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Detalles Bibliográficos
Autores principales: Wörsdörfer, Philipp, Dalda, Nahide, Kern, Anna, Krüger, Sarah, Wagner, Nicole, Kwok, Chee Keong, Henke, Erik, Ergün, Süleyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821804/
https://www.ncbi.nlm.nih.gov/pubmed/31666641
http://dx.doi.org/10.1038/s41598-019-52204-7