Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro

DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key protein associated with Parkinson’s disease. The underlying molecular mechanism behind α-synuclein aggregation inhib...

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Detalles Bibliográficos
Autores principales: Kumar, Roshan, Kumar, Sanjay, Hanpude, Pranita, Singh, Abhishek Kumar, Johari, Tanu, Majumder, Sushanta, Maiti, Tushar Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821844/
https://www.ncbi.nlm.nih.gov/pubmed/31701024
http://dx.doi.org/10.1038/s42003-019-0644-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821844/
https://www.ncbi.nlm.nih.gov/pubmed/31701024
http://dx.doi.org/10.1038/s42003-019-0644-7

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