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Details of the cooperative binding of piperlongumine with rat serum albumin obtained by spectroscopic and computational analyses
Piperlongumine (PPL) has presented a variety of important pharmacological activities. In recent pharmacokinetics studies in rats, this molecule reached 76.39% of bioavailability. Although PPL is present in the bloodstream, no information is found on the interaction between PPL and rat serum albumin...
Autores principales: | Povinelli, Ana Paula Ribeiro, Zazeri, Gabriel, de Freitas Lima, Marcelo, Cornélio, Marinônio Lopes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821919/ https://www.ncbi.nlm.nih.gov/pubmed/31666676 http://dx.doi.org/10.1038/s41598-019-52187-5 |
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