Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase

Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are needed to overcome a myriad of resistance mechanisms in A. baumannii. In this study, we screened an open-source Pathogen Box library for anti-A. baumannii compounds. Compoun...

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Detalles Bibliográficos
Autores principales: Songsungthong, Warangkhana, Yongkiettrakul, Suganya, Bohan, Louise E., Nicholson, Eric S., Prasopporn, Sunisa, Chaiyen, Pimchai, Leartsakulpanich, Ubolsree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821926/
https://www.ncbi.nlm.nih.gov/pubmed/31666629
http://dx.doi.org/10.1038/s41598-019-52176-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821926/
https://www.ncbi.nlm.nih.gov/pubmed/31666629
http://dx.doi.org/10.1038/s41598-019-52176-8

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