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Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase
Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are needed to overcome a myriad of resistance mechanisms in A. baumannii. In this study, we screened an open-source Pathogen Box library for anti-A. baumannii compounds. Compoun...
Autores principales: | Songsungthong, Warangkhana, Yongkiettrakul, Suganya, Bohan, Louise E., Nicholson, Eric S., Prasopporn, Sunisa, Chaiyen, Pimchai, Leartsakulpanich, Ubolsree |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821926/ https://www.ncbi.nlm.nih.gov/pubmed/31666629 http://dx.doi.org/10.1038/s41598-019-52176-8 |
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