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(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

BACKGROUND: Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view of the involvement of mechanisms other than the N-methyl-D-aspartate receptor in k...

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Detalles Bibliográficos
Autores principales: Ago, Yukio, Tanabe, Wataru, Higuchi, Momoko, Tsukada, Shinji, Tanaka, Tatsunori, Yamaguchi, Takumi, Igarashi, Hisato, Yokoyama, Rei, Seiriki, Kaoru, Kasai, Atsushi, Nakazawa, Takanobu, Nakagawa, Shinsaku, Hashimoto, Kenji, Hashimoto, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822138/
https://www.ncbi.nlm.nih.gov/pubmed/31325908
http://dx.doi.org/10.1093/ijnp/pyz041