Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells

Poly(ADP‐ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR‐deficient tumors efficiently respond to PARP inhibition and often acquire resistance. It is therefore important...

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Detalles Bibliográficos
Autores principales: Schoonen, Pepijn M., Kok, Yannick P., Wierenga, Elles, Bakker, Bjorn, Foijer, Floris, Spierings, Diana C. J., van Vugt, Marcel A. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822251/
https://www.ncbi.nlm.nih.gov/pubmed/31529615
http://dx.doi.org/10.1002/1878-0261.12573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822251/
https://www.ncbi.nlm.nih.gov/pubmed/31529615
http://dx.doi.org/10.1002/1878-0261.12573

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