HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

OBJECTIVE: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investigated if HSP70 modulates cholesterol accumulation...

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Detalles Bibliográficos
Autores principales: Gungor, Burcin, Vanharanta, Lauri, Hölttä-Vuori, Maarit, Pirhonen, Juho, Petersen, Nikolaj H.T., Gramolelli, Silvia, Ojala, Päivi M., Kirkegaard, Thomas, Ikonen, Elina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822257/
https://www.ncbi.nlm.nih.gov/pubmed/31327756
http://dx.doi.org/10.1016/j.molmet.2019.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822257/
https://www.ncbi.nlm.nih.gov/pubmed/31327756
http://dx.doi.org/10.1016/j.molmet.2019.07.005

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