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HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo
OBJECTIVE: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investigated if HSP70 modulates cholesterol accumulation...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822257/ https://www.ncbi.nlm.nih.gov/pubmed/31327756 http://dx.doi.org/10.1016/j.molmet.2019.07.005 |