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Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice

Olive oil could attenuate carbon tetrachloride (CCl(4)) induced liver fibrosis (LF) in mouse model. The present study aimed to evaluate the effects of other common oils on CCl(4) induced LF. Healthy male ICR mice were administered with CCl(4) intraperitoneally at 2.5 ml/kg twice a week for total 3 w...

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Autores principales: Gao, Yanan, Li, Xuguang, Gao, Qiang, Fan, Li, Jin, Haobin, Guo, Yueping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822505/
https://www.ncbi.nlm.nih.gov/pubmed/31481526
http://dx.doi.org/10.1042/BSR20191913
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author Gao, Yanan
Li, Xuguang
Gao, Qiang
Fan, Li
Jin, Haobin
Guo, Yueping
author_facet Gao, Yanan
Li, Xuguang
Gao, Qiang
Fan, Li
Jin, Haobin
Guo, Yueping
author_sort Gao, Yanan
collection PubMed
description Olive oil could attenuate carbon tetrachloride (CCl(4)) induced liver fibrosis (LF) in mouse model. The present study aimed to evaluate the effects of other common oils on CCl(4) induced LF. Healthy male ICR mice were administered with CCl(4) intraperitoneally at 2.5 ml/kg twice a week for total 3 weeks. Mice were pre-treated with olive oil, soybean oil, corn oil or lard oil. After treatment, histopathological changes were observed using Masson trichrome staining, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), hydroxyproline (HYP) and triglyceride (TG) were measured by commercial kits. The expression of LF related genes was detected by quantitative real-time PCR. We found that soybean oil or olive oil significantly reduced ALT and AST levels in serum, and MDA, HYP and TG levels in the liver, compared with corn oil or lard oil. Moreover, Masson trichrome staining and real-time PCR showed that the mice treated with CCl(4) dissolved in soybean oil or olive oil had less fibrosis and apoptosis in the liver comparted to the mice treated with CCl(4) dissolved in corn oil or lard oil. In conclusion, soybean oil but not corn or lard oil exerts protective effects against CCl(4) induced LF in mice, possibly due to its antioxidant activity.
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spelling pubmed-68225052019-11-06 Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice Gao, Yanan Li, Xuguang Gao, Qiang Fan, Li Jin, Haobin Guo, Yueping Biosci Rep Therapeutics & Molecular Medicine Olive oil could attenuate carbon tetrachloride (CCl(4)) induced liver fibrosis (LF) in mouse model. The present study aimed to evaluate the effects of other common oils on CCl(4) induced LF. Healthy male ICR mice were administered with CCl(4) intraperitoneally at 2.5 ml/kg twice a week for total 3 weeks. Mice were pre-treated with olive oil, soybean oil, corn oil or lard oil. After treatment, histopathological changes were observed using Masson trichrome staining, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), hydroxyproline (HYP) and triglyceride (TG) were measured by commercial kits. The expression of LF related genes was detected by quantitative real-time PCR. We found that soybean oil or olive oil significantly reduced ALT and AST levels in serum, and MDA, HYP and TG levels in the liver, compared with corn oil or lard oil. Moreover, Masson trichrome staining and real-time PCR showed that the mice treated with CCl(4) dissolved in soybean oil or olive oil had less fibrosis and apoptosis in the liver comparted to the mice treated with CCl(4) dissolved in corn oil or lard oil. In conclusion, soybean oil but not corn or lard oil exerts protective effects against CCl(4) induced LF in mice, possibly due to its antioxidant activity. Portland Press Ltd. 2019-10-11 /pmc/articles/PMC6822505/ /pubmed/31481526 http://dx.doi.org/10.1042/BSR20191913 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Therapeutics & Molecular Medicine
Gao, Yanan
Li, Xuguang
Gao, Qiang
Fan, Li
Jin, Haobin
Guo, Yueping
Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title_full Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title_fullStr Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title_full_unstemmed Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title_short Differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
title_sort differential effects of olive oil, soybean oil, corn oil and lard oil on carbon tetrachloride-induced liver fibrosis in mice
topic Therapeutics & Molecular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822505/
https://www.ncbi.nlm.nih.gov/pubmed/31481526
http://dx.doi.org/10.1042/BSR20191913
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