Genetic changes in the EPAS1 gene between Tibetan and Han ethnic groups and adaptation to the plateau hypoxic environment

In the Chinese Han population, prolonged exposure to hypoxic conditions can promote compensatory erythropoiesis which improves hypoxemia. However, Tibetans have developed unique phenotypes, such as downregulation of the hypoxia-inducible factor pathway through EPAS1 gene mutation, thus the mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Cuiying, Li, Xiaowei, Xiao, Jun, Liu, Juan, Fan, Xiu, Fan, Fengyan, Lei, Huifen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Evolutionary Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822597/
https://www.ncbi.nlm.nih.gov/pubmed/31681516
http://dx.doi.org/10.7717/peerj.7943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822597/
https://www.ncbi.nlm.nih.gov/pubmed/31681516
http://dx.doi.org/10.7717/peerj.7943

Ejemplares similares