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Resolution of angstrom-scale protein-conformational changes by analyzing fluorescence anisotropy

Conformational changes within typical protein molecules are rapid and small, making their quantitative resolution challenging. These changes generally involve rotational motions, and may thus be resolved by determining changes in the orientation of a fluorescent label that assumes a unique orientati...

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Detalles Bibliográficos
Autores principales: Lewis, John H., Lu, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822697/
https://www.ncbi.nlm.nih.gov/pubmed/31488909
http://dx.doi.org/10.1038/s41594-019-0274-2