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A multi-scale coevolutionary approach to predict interactions between protein domains

Interacting proteins and protein domains coevolve on multiple scales, from their correlated presence across species, to correlations in amino-acid usage. Genomic databases provide rapidly growing data for variability in genomic protein content and in protein sequences, calling for computational pred...

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Detalles Bibliográficos
Autores principales: Croce, Giancarlo, Gueudré, Thomas, Ruiz Cuevas, Maria Virginia, Keidel, Victoria, Figliuzzi, Matteo, Szurmant, Hendrik, Weigt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822775/
https://www.ncbi.nlm.nih.gov/pubmed/31634362
http://dx.doi.org/10.1371/journal.pcbi.1006891