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LASSI: A lattice model for simulating phase transitions of multivalent proteins

Many biomolecular condensates form via spontaneous phase transitions that are driven by multivalent proteins. These molecules are biological instantiations of associative polymers that conform to a so-called stickers-and-spacers architecture. The stickers are protein-protein or protein-RNA interacti...

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Detalles Bibliográficos
Autores principales: Choi, Jeong-Mo, Dar, Furqan, Pappu, Rohit V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822780/
https://www.ncbi.nlm.nih.gov/pubmed/31634364
http://dx.doi.org/10.1371/journal.pcbi.1007028