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Development of a Lyophilized Formulation of Pegaspargase and Comparability Versus Liquid Pegaspargase
INTRODUCTION: Pegaspargase, a pegylated asparaginase, is a core component in the treatment of acute lymphoblastic leukemia. Pegaspargase in liquid form has a limited shelf life of 8 months due to depegylation, leading to changes in purity and potency over time. Lyophilization is an approach that can...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Healthcare
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822849/ https://www.ncbi.nlm.nih.gov/pubmed/31140125 http://dx.doi.org/10.1007/s12325-019-00988-5 |