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Development of a Lyophilized Formulation of Pegaspargase and Comparability Versus Liquid Pegaspargase

INTRODUCTION: Pegaspargase, a pegylated asparaginase, is a core component in the treatment of acute lymphoblastic leukemia. Pegaspargase in liquid form has a limited shelf life of 8 months due to depegylation, leading to changes in purity and potency over time. Lyophilization is an approach that can...

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Detalles Bibliográficos
Autores principales:	Faschinger, Alexander M., Sessler, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Healthcare 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822849/ https://www.ncbi.nlm.nih.gov/pubmed/31140125 http://dx.doi.org/10.1007/s12325-019-00988-5

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