LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression

LSD1 (KDM1A) is a histone demethylase that plays both oncogenic and tumor suppressor roles in breast cancer. However, the exact contexts under which it plays these opposite functions remain largely elusive. By characterizing its role in luminal breast epithelial cells, here we show that inhibition o...

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Detalles Bibliográficos
Autores principales: Hu, Xin, Xiang, Dongxi, Xie, Ying, Tao, Luwei, Zhang, Yu, Jin, Yue, Pinello, Luca, Wan, Youzhong, Yuan, Guo-Cheng, Li, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823153/
https://www.ncbi.nlm.nih.gov/pubmed/31409898
http://dx.doi.org/10.1038/s41388-019-0923-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823153/
https://www.ncbi.nlm.nih.gov/pubmed/31409898
http://dx.doi.org/10.1038/s41388-019-0923-2

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