Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors

Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val(103) possessing a Ser195Ala mutation relative to wild-type PR3-Val(103)—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whethe...

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Detalles Bibliográficos
Autores principales: Pang, Yuan-Ping, Casal Moura, Marta, Thompson, Gwen E., Nelson, Darlene R., Hummel, Amber M., Jenne, Dieter E., Emerling, Daniel, Volkmuth, Wayne, Robinson, William H., Specks, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823208/
https://www.ncbi.nlm.nih.gov/pubmed/31708920
http://dx.doi.org/10.3389/fimmu.2019.02467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823208/
https://www.ncbi.nlm.nih.gov/pubmed/31708920
http://dx.doi.org/10.3389/fimmu.2019.02467

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