Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus

Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are incompletely characterized. Histone deactylase 6 (HDAC6) is a unique cytoplas...

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Detalles Bibliográficos
Autores principales: Ren, Jingjing, Catalina, Michelle D., Eden, Kristin, Liao, Xiaofeng, Read, Kaitlin A., Luo, Xin, McMillan, Ryan P., Hulver, Matthew W., Jarpe, Matthew, Bachali, Prathyusha, Grammer, Amrie C., Lipsky, Peter E., Reilly, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823248/
https://www.ncbi.nlm.nih.gov/pubmed/31708928
http://dx.doi.org/10.3389/fimmu.2019.02512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823248/
https://www.ncbi.nlm.nih.gov/pubmed/31708928
http://dx.doi.org/10.3389/fimmu.2019.02512

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