Cargando…

Targeting ERβ in Macrophage Reduces Crown-like Structures in Adipose Tissue by Inhibiting Osteopontin and HIF-1α

Proinflammatory processes in adipose tissue contribute to development of breast cancer and insulin resistance. Crown-like structures (CLS) are histologic hallmarks of the proinflammatory process in adipose tissue. CLS are microscopic foci of dying adipocytes surrounded by macrophages mostly derived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Li, Zhao, Rui-peng, Song, Xiao-yu, Wu, Wan-fu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823357/ https://www.ncbi.nlm.nih.gov/pubmed/31673032 http://dx.doi.org/10.1038/s41598-019-52265-8

Ejemplares similares

Does osteopontin induce adipose tissue inflammation by local macrophage proliferation?
por: Kahles, Florian, et al.
Publicado: (2016)

Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
por: Dai, Bingyang, et al.
Publicado: (2022)

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
por: Kim, Min, et al.
Publicado: (2014)

Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity
por: Tardelli, Matteo, et al.
Publicado: (2016)

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity
por: Sharma, Monika, et al.
Publicado: (2020)

Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction
por: Sawaki, Daigo, et al.
Publicado: (2023)

Osteopontin: Relation between Adipose Tissue and Bone Homeostasis
por: De Fusco, Carolina, et al.
Publicado: (2017)

Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity
por: Bertola, Adeline, et al.
Publicado: (2009)

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
por: Ahlqvist, Emma, et al.
Publicado: (2013)

Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway
por: Cao, Lei, et al.
Publicado: (2015)

Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice
por: Lancha, Andoni, et al.
Publicado: (2014)

Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer
por: Maliniak, Maret L., et al.
Publicado: (2021)

B lymphocytes in human subcutaneous adipose crown-like structures
por: McDonnell, Marie E., et al.
Publicado: (2012)

HIF-1α-Overexpressing Mesenchymal Stem Cells Attenuate Colitis by Regulating M1-like Macrophages Polarization toward M2-like Macrophages
por: Zhu, Wenya, et al.
Publicado: (2023)

In Vitro and In Vivo Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue
por: Śmieszek, Agnieszka, et al.
Publicado: (2015)

Presence of Adenovirus-36 DNA in Adipose Tissue of Women: Relationship with Adipocyte Morphology and the Expression of C/EBPβ and HIF-1α
por: Barrera-Alcocer, Jorge, et al.
Publicado: (2021)

Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy
por: Faria, Sara Socorro, et al.
Publicado: (2020)

3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue
por: Geng, Junlong, et al.
Publicado: (2021)

Osteopontin–integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer
por: Fan, Chi-Shuan, et al.
Publicado: (2017)

The Osteopontin Level in Liver, Adipose Tissue and Serum Is Correlated with Fibrosis in Patients with Alcoholic Liver Disease
por: Patouraux, Stéphanie, et al.
Publicado: (2012)

Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue
por: Cao, Weina, et al.
Publicado: (2019)

Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue
por: Dixit, Vishwa Deep
Publicado: (2013)

Sirt1 coordinates with ERα to regulate autophagy and adiposity
por: Tao, Zhipeng, et al.
Publicado: (2021)

Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer
por: Maliniak, Maret L., et al.
Publicado: (2020)

Tissue factor, osteopontin, α(v)β(3) integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression
por: Takano, S, et al.
Publicado: (2000)

Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration
por: Lin, Yuli, et al.
Publicado: (2021)

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro
por: Pescador, Nuria, et al.
Publicado: (2021)

Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity
por: Nance, Sierra A., et al.
Publicado: (2022)

A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition
por: Miyachi, Yasutaka, et al.
Publicado: (2018)

Inhibition of Survivin Reduces HIF-1α, TGF-β1 and TFE3 in Salivary Adenoid Cystic Carcinoma
por: Wang, Yu-Fan, et al.
Publicado: (2014)

Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients
por: Mullooly, Maeve, et al.
Publicado: (2017)

Crown-like structures in breast adipose tissue of breast cancer patients: associations with CD68 expression, obesity, metabolic factors and prognosis
por: Chang, Martin C., et al.
Publicado: (2021)

The Role of Osteopontin in Tumor Progression Through Tumor-Associated Macrophages
por: Tan, Yuying, et al.
Publicado: (2022)

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis
por: Wu, Keke, et al.
Publicado: (2023)

Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα
por: Collins, Frances, et al.
Publicado: (2009)

Correction: Sirt1 coordinates with ERα to regulate autophagy and adiposity
por: Tao, Zhipeng, et al.
Publicado: (2023)

ERβ regulation of NF-κB activation in prostate cancer is mediated by HIF-1
por: Mak, Paul, et al.
Publicado: (2015)

Omental Macrophagic “Crown-like Structures” Are Associated with Poor Prognosis in Advanced-Stage Serous Ovarian Cancer
por: Liang, Yu-Ling, et al.
Publicado: (2021)

Collagen XV Promotes ER Stress-Induced Inflammation through Activating Integrin β1/FAK Signaling Pathway and M1 Macrophage Polarization in Adipose Tissue
por: Li, Changxing, et al.
Publicado: (2021)

RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling
por: Niu, Zhiguo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ncei5gk6elv6m7r0uakd7r3s61