Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Tight control of centriole duplication is critical for normal chromosome segregation and the maintenance of genomic stability. Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis. How Plk4 dynamically promotes its symmetry-breaking relocalization and achieves its procentriole-assemb...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Jung-Eun, Zhang, Liang, Bang, Jeong Kyu, Andresson, Thorkell, DiMaio, Frank, Lee, Kyung S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823436/
https://www.ncbi.nlm.nih.gov/pubmed/31672968
http://dx.doi.org/10.1038/s41467-019-12619-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823436/
https://www.ncbi.nlm.nih.gov/pubmed/31672968
http://dx.doi.org/10.1038/s41467-019-12619-2

Ejemplares similares