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Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Tight control of centriole duplication is critical for normal chromosome segregation and the maintenance of genomic stability. Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis. How Plk4 dynamically promotes its symmetry-breaking relocalization and achieves its procentriole-assemb...

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Detalles Bibliográficos
Autores principales:	Park, Jung-Eun, Zhang, Liang, Bang, Jeong Kyu, Andresson, Thorkell, DiMaio, Frank, Lee, Kyung S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823436/ https://www.ncbi.nlm.nih.gov/pubmed/31672968 http://dx.doi.org/10.1038/s41467-019-12619-2

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