Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE

Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term treatment. Gene therapy is being considered as a promising tool to treat AMD. We found that increased activation of Rap1a in the retinal pigment epithelium (RPE) reduces oxidative signaling to maintain...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Kunz, Eric, Stoddard, Gregory J., Hauswirth, William W., Hartnett, M. Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823539/
https://www.ncbi.nlm.nih.gov/pubmed/31673119
http://dx.doi.org/10.1038/s41598-019-52163-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823539/
https://www.ncbi.nlm.nih.gov/pubmed/31673119
http://dx.doi.org/10.1038/s41598-019-52163-z

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