GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome

Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models...

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Detalles Bibliográficos
Autores principales: Seppa, Kadri, Toots, Maarja, Reimets, Riin, Jagomäe, Toomas, Koppel, Tuuliki, Pallase, Maia, Hasselholt, Stine, Krogsbæk Mikkelsen, Maiken, Randel Nyengaard, Jens, Vasar, Eero, Terasmaa, Anton, Plaas, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823542/
https://www.ncbi.nlm.nih.gov/pubmed/31673100
http://dx.doi.org/10.1038/s41598-019-52295-2