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Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells
We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including hyperactivity and anxiety. The defects are due to rapid loss of...
Autores principales: | Li, Lin, Jin, Jianliang, Yang, Xiang-Jiao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823663/ https://www.ncbi.nlm.nih.gov/pubmed/31569049 http://dx.doi.org/10.1016/j.isci.2019.09.015 |
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