Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine

The effects of L-3-4-dyhydroxyphenylalanine (L-DOPA) treatment for replacing the dopamine (DA) loss in Parkinson’s disease (PD) progressively wear off and are hindered by the development of dyskinesia, prompting the search for new treatments. The orphan G protein-coupled receptor 88 (Gpr88) represen...

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Detalles Bibliográficos
Autores principales: Ingallinesi, Manuela, Galet, Benjamin, Pegon, Jonathan, Faucon Biguet, Nicole, Do Thi, Anh, Millan, Mark J, Mannoury la Cour, Clotilde, Meloni, Rolando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823866/
https://www.ncbi.nlm.nih.gov/pubmed/31708775
http://dx.doi.org/10.3389/fphar.2019.01233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823866/
https://www.ncbi.nlm.nih.gov/pubmed/31708775
http://dx.doi.org/10.3389/fphar.2019.01233

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