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Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine

The effects of L-3-4-dyhydroxyphenylalanine (L-DOPA) treatment for replacing the dopamine (DA) loss in Parkinson’s disease (PD) progressively wear off and are hindered by the development of dyskinesia, prompting the search for new treatments. The orphan G protein-coupled receptor 88 (Gpr88) represen...

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Detalles Bibliográficos
Autores principales:	Ingallinesi, Manuela, Galet, Benjamin, Pegon, Jonathan, Faucon Biguet, Nicole, Do Thi, Anh, Millan, Mark J, Mannoury la Cour, Clotilde, Meloni, Rolando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823866/ https://www.ncbi.nlm.nih.gov/pubmed/31708775 http://dx.doi.org/10.3389/fphar.2019.01233

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