Homotaurine Treatment Enhances CD4(+) and CD8(+) Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice

Immune cells express γ-aminobutyric acid receptors (GABA-R), and GABA administration can inhibit effector T cell responses in models of autoimmune disease. The pharmacokinetic properties of GABA, however, may be suboptimal for clinical applications. The amino acid homotaurine is a type A GABA-R (GAB...

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Detalles Bibliográficos
Autores principales: Tian, Jide, Dang, Hoa, O’Laco, Karen Anne, Song, Min, Tiu, Bryan-Clement, Gilles, Spencer, Zakarian, Christina, Kaufman, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823932/
https://www.ncbi.nlm.nih.gov/pubmed/31636084
http://dx.doi.org/10.4049/immunohorizons.1900019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823932/
https://www.ncbi.nlm.nih.gov/pubmed/31636084
http://dx.doi.org/10.4049/immunohorizons.1900019

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