A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib

BACKGROUND: Baricitinib, with a 2-(1-(ethylsulfonyl)azetidin-3-yl)acetonitrile moiety at N-2 position of the pyrazol skeleton, is an oral and selective reversible inhibitor of the JAK1 and JAK2 and displays potent anti-inflammatory activity. Several research-scale synthetic methods have been reporte...

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Detalles Bibliográficos
Autores principales: Cui, Xin, Du, Junming, Jia, Zongqing, Wang, Xilong, Jia, Haiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824028/
https://www.ncbi.nlm.nih.gov/pubmed/31696160
http://dx.doi.org/10.1186/s13065-019-0639-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824028/
https://www.ncbi.nlm.nih.gov/pubmed/31696160
http://dx.doi.org/10.1186/s13065-019-0639-y

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