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Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One such isoform, Drp1(ABCD), contains all four alternative exons and is spec...

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Detalles Bibliográficos
Autores principales: Itoh, Kie, Murata, Daisuke, Kato, Takashi, Yamada, Tatsuya, Araki, Yoichi, Saito, Atsushi, Adachi, Yoshihiro, Igarashi, Atsushi, Li, Shuo, Pletnikov, Mikhail, Huganir, Richard L, Watanabe, Shigeki, Kamiya, Atsushi, Iijima, Miho, Sesaki, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824841/
https://www.ncbi.nlm.nih.gov/pubmed/31603426
http://dx.doi.org/10.7554/eLife.44739