Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction

CYP3A4, a cytochrome P450 enzyme regulated by the nuclear receptor PXR, is involved in most of the drug metabolizing pathways. Studying the regulation/induction of CYP3A4 and PXR is critical in toxicology and drug-drug interaction (DDI) studies. Primary human hepatocytes constitute the preferred in...

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Detalles Bibliográficos
Autores principales: Bulutoglu, Beyza, Mert, Safak, Rey-Bedón, Camilo, Deng, Sarah L., Yarmush, Martin L., Usta, O. Berk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825149/
https://www.ncbi.nlm.nih.gov/pubmed/31676845
http://dx.doi.org/10.1038/s41598-019-52174-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825149/
https://www.ncbi.nlm.nih.gov/pubmed/31676845
http://dx.doi.org/10.1038/s41598-019-52174-w

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