Mechanism and Consequences of The Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose

Renal hypoxia and loss of proximal tubular cells (PTC) are relevant in diabetic nephropathy. Hypoxia inhibits hypoxia-inducible factor-1α (HIF-1α) degradation, which leads to cellular adaptive responses through HIF-1-dependent activation of gene hypoxia-responsive elements (HRE). However, the diabet...

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Detalles Bibliográficos
Autores principales: García-Pastor, Coral, Benito-Martínez, Selma, Moreno-Manzano, Victoria, Fernández-Martínez, Ana B., Lucio-Cazaña, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825166/
https://www.ncbi.nlm.nih.gov/pubmed/31676796
http://dx.doi.org/10.1038/s41598-019-52310-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825166/
https://www.ncbi.nlm.nih.gov/pubmed/31676796
http://dx.doi.org/10.1038/s41598-019-52310-6

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