Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Overinhibition is assumed one of the main causes of cognitive deficits (e.g. memory impairment) in mouse models of Down syndrome (DS). Yet the mechanisms that drive such exaggerated synaptic inhibition and their behavioral effects remain unclear. Here we report the existence of bidirectional alterat...

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Detalles Bibliográficos
Autores principales: Valbuena, Sergio, García, Álvaro, Mazier, Wilfrid, Paternain, Ana V., Lerma, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825203/
https://www.ncbi.nlm.nih.gov/pubmed/31676751
http://dx.doi.org/10.1038/s41467-019-13004-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825203/
https://www.ncbi.nlm.nih.gov/pubmed/31676751
http://dx.doi.org/10.1038/s41467-019-13004-9

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