Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish a key role of FASN during transformation. FASN is required for eliciting the anaplerotic shift of the Krebs cycl...

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Detalles Bibliográficos
Autores principales: Bueno, Maria J., Jimenez-Renard, Veronica, Samino, Sara, Capellades, Jordi, Junza, Alejandra, López-Rodríguez, María Luz, Garcia-Carceles, Javier, Lopez-Fabuel, Irene, Bolaños, Juan P., Chandel, Navdeep S., Yanes, Oscar, Colomer, Ramon, Quintela-Fandino, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825217/
https://www.ncbi.nlm.nih.gov/pubmed/31676791
http://dx.doi.org/10.1038/s41467-019-13028-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825217/
https://www.ncbi.nlm.nih.gov/pubmed/31676791
http://dx.doi.org/10.1038/s41467-019-13028-1

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