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Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish a key role of FASN during transformation. FASN is required for eliciting the anaplerotic shift of the Krebs cycl...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825217/ https://www.ncbi.nlm.nih.gov/pubmed/31676791 http://dx.doi.org/10.1038/s41467-019-13028-1 |