Cargando…

The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms

HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechanism by which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Xiaobo, Rosales, Alan, Karttunen, Heidi, Bommana, Geetha M., Tandoh, Buadi, Yi, Zhengzi, Habib, Zainab, D’Agati, Vivette, Zhang, Weijia, Ross, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825220/ https://www.ncbi.nlm.nih.gov/pubmed/31676833 http://dx.doi.org/10.1038/s41598-019-52278-3

Ejemplares similares

Publisher Correction: The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms
por: Gao, Xiaobo, et al.
Publicado: (2020)

Renal HIV Expression Is Unaffected by Serum LPS Levels in an HIV Transgenic Mouse Model of LPS Induced Kidney Injury
por: Leventhal, Jeremy S., et al.
Publicado: (2011)

Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps
por: Zhang, Ying, et al.
Publicado: (2014)

Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance
por: Nakashima, Masaaki, et al.
Publicado: (2016)

Evaluation of novel protease inhibitors against darunavir‐resistant variants of HIV type 1
por: Inoue, Mari, et al.
Publicado: (2016)

In Search of C3G Tissue Biomarkers
por: D’Agati, Vivette D., et al.
Publicado: (2019)

Combating HIV resistance – focus on darunavir
por: Tremblay, Cécile L
Publicado: (2008)

Role of darunavir in the management of HIV infection
por: Lascar, R Monica, et al.
Publicado: (2009)

Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir
por: Yu, Yuqi, et al.
Publicado: (2015)

Management of Antiretroviral Therapy with Boosted Protease Inhibitors—Darunavir/Ritonavir or Darunavir/Cobicistat
por: Marin, Ruxandra-Cristina, et al.
Publicado: (2021)

Revealing Origin of Decrease in Potency of Darunavir and Amprenavir against HIV-2 relative to HIV-1 Protease by Molecular Dynamics Simulations
por: Chen, Jianzhong, et al.
Publicado: (2014)

Darunavir-Resistant HIV-1 Protease Constructs Uphold a Conformational Selection Hypothesis for Drug Resistance
por: Liu, Zhanglong, et al.
Publicado: (2020)

Long term effect of switching to darunavir/ritonavir in HIV infected patients previously on protease inhibitor therapy
por: Ucciferri, Claudio, et al.
Publicado: (2016)

A Fresh Perspective on Monoclonal Gammopathies of Renal Significance
por: Aucouturier, Pierre, et al.
Publicado: (2021)

De Novo and Relapsing Glomerular Diseases After COVID-19 Vaccination: What Do We Know So Far?
por: Bomback, Andrew S., et al.
Publicado: (2021)

C-MYC–induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent
por: Trudel, Marie, et al.
Publicado: (1997)

Profile of darunavir in the management of treatment-experienced HIV patients
por: Wolfe, Cameron, et al.
Publicado: (2009)

Darunavir-based dual therapy in HIV experienced patients
por: Sterrantino, Gaetana, et al.
Publicado: (2014)

Erratum. Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression. Diabetes 2019;68:2301–2314
por: Fan, Ying, et al.
Publicado: (2020)

Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression
por: Fan, Ying, et al.
Publicado: (2019)

Histologic correlates of gross hematuria following Moderna COVID-19 vaccine in patients with IgA nephropathy
por: Kudose, Satoru, et al.
Publicado: (2021)

Expression of HIV transgene aggravates kidney injury in diabetic mice
por: Mallipattu, Sandeep K, et al.
Publicado: (2013)

Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS
por: Mishra, Tulsidas, et al.
Publicado: (2014)

Repurposing HIV Protease Inhibitors Atazanavir and Darunavir as Antifungal Treatments against Candida albicans Infections: An In Vitro and In Vivo Study
por: Fenley, Juliana de C., et al.
Publicado: (2022)

Protease mutations emerging on darunavir in protease inhibitor-naïve and experienced patients in the UK
por: El Bouzidi, Kate, et al.
Publicado: (2014)

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops
por: Kuiper, Benjamin D., et al.
Publicado: (2015)

Profile of darunavir in the treatment of HIV-infected pediatric and adolescent patients
por: Dobroszycki, Joanna, et al.
Publicado: (2011)

Darunavir Population Pharmacokinetic Model Based on HIV Outpatient Data
por: Daskapan, Alper, et al.
Publicado: (2019)

New developments in the genetics, pathogenesis, and therapy of IgA nephropathy
por: Magistroni, Riccardo, et al.
Publicado: (2015)

Refinement of the HIVAN1 Susceptibility Locus on Chr. 3A1-A3 via Generation of Sub-Congenic Strains
por: Papeta, Natalia, et al.
Publicado: (2016)

Collapsing Glomerulopathy Associated With Hydrophilic Polymer Emboli
por: Kudose, Satoru, et al.
Publicado: (2018)

Atypical Infection-Related Glomerulonephritis With “Masked” IgG-Kappa Crystalline Hump-Like Deposits
por: DiFranza, Lanny T., et al.
Publicado: (2020)

The structural, dynamic, and thermodynamic basis of darunavir resistance of a heavily mutated HIV-1 protease using molecular dynamics simulation
por: Shabanpour, Yaser, et al.
Publicado: (2022)

Validation Study on the Utility of Immunoglobulin Heavy/Light Chain Immunofluorescence in Kidney Biopsies With Potential Monoclonal Gammopathy of Renal Significance Lesions
por: Kudose, Satoru, et al.
Publicado: (2022)

Comparison of Tolerability and Impact on Metabolic Profiles of Antiretroviral Regimens Containing Darunavir/Ritonavir or Darunavir/Cobicistat in Romanian HIV Infected Patients
por: Marin, Ruxandra-Cristina, et al.
Publicado: (2021)

Acute kidney injury after hepatic ischemia and reperfusion injury in mice
por: Lee, H. Thomas, et al.
Publicado: (2008)

Unusual Case of Lipoprotein Glomerulopathy First Diagnosed in a Protocol Kidney Allograft Biopsy
por: Batal, Ibrahim, et al.
Publicado: (2018)

Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine
por: D’Agati, Vivette D., et al.
Publicado: (2021)

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
por: Giacco, Ferdinando, et al.
Publicado: (2014)

Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir
por: Neely, Michael, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_an8f6kgainora5iuole8825rv0