A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor

An Australian estuarine isolate of Penicillium sp. MST-MF667 yielded 3 tetrapeptides named the bilaids with an unusual alternating LDLD chirality. Given their resemblance to known short peptide opioid agonists, we elucidated that they were weak (K(i) low micromolar) μ-opioid agonists, which led to t...

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Detalles Bibliográficos
Autores principales: Dekan, Zoltan, Sianati, Setareh, Yousuf, Arsalan, Sutcliffe, Katy J., Gillis, Alexander, Mallet, Christophe, Singh, Paramjit, Jin, Aihua H., Wang, Anna M., Mohammadi, Sarasa A., Stewart, Michael, Ratnayake, Ranjala, Fontaine, Frank, Lacey, Ernest, Piggott, Andrew M., Du, Yan P., Canals, Meritxell, Sessions, Richard B., Kelly, Eamonn, Capon, Robert J., Alewood, Paul F., Christie, MacDonald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825270/
https://www.ncbi.nlm.nih.gov/pubmed/31611414
http://dx.doi.org/10.1073/pnas.1908662116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825270/
https://www.ncbi.nlm.nih.gov/pubmed/31611414
http://dx.doi.org/10.1073/pnas.1908662116

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