Cargando…

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor

An Australian estuarine isolate of Penicillium sp. MST-MF667 yielded 3 tetrapeptides named the bilaids with an unusual alternating LDLD chirality. Given their resemblance to known short peptide opioid agonists, we elucidated that they were weak (K(i) low micromolar) μ-opioid agonists, which led to t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dekan, Zoltan, Sianati, Setareh, Yousuf, Arsalan, Sutcliffe, Katy J., Gillis, Alexander, Mallet, Christophe, Singh, Paramjit, Jin, Aihua H., Wang, Anna M., Mohammadi, Sarasa A., Stewart, Michael, Ratnayake, Ranjala, Fontaine, Frank, Lacey, Ernest, Piggott, Andrew M., Du, Yan P., Canals, Meritxell, Sessions, Richard B., Kelly, Eamonn, Capon, Robert J., Alewood, Paul F., Christie, MacDonald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825270/ https://www.ncbi.nlm.nih.gov/pubmed/31611414 http://dx.doi.org/10.1073/pnas.1908662116

Ejemplares similares

Directed Discovery of Tetrapeptide Emulsifiers
por: Scott, Gary G., et al.
Publicado: (2022)

Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor
por: Sutcliffe, Katy J., et al.
Publicado: (2017)

Enantioselective Sulfonylation Reactions Mediated by a Tetrapeptide Catalyst
por: Fiori, Kristin Williams, et al.
Publicado: (2009)

Anti-tumour effect of the physiological tetrapeptide, tuftsin.
por: Nishioka, K.
Publicado: (1979)

Fibronectin tetrapeptide is target for syphilis spirochete cytadherence
Publicado: (1985)

Identification of a human estrogen receptor α tetrapeptidic fragment with dual antiproliferative and anti-nociceptive action
por: Jouffre, Baptiste, et al.
Publicado: (2023)

Analysis of Mechanically Activated Ion Channels at the Cell-Substrate Interface: Combining Pillar Arrays and Whole-Cell Patch-Clamp
por: Sianati, Setareh, et al.
Publicado: (2019)

Exploring the Energy Landscapes of Cyclic Tetrapeptides with Discrete Path Sampling
por: Oakley, Mark T., et al.
Publicado: (2012)

Milk Protein-Derived Antioxidant Tetrapeptides as Potential Hypopigmenting Agents
por: Kong, Saerom, et al.
Publicado: (2020)

Twists or turns: stabilising alpha vs. beta turns in tetrapeptides
por: Hoang, Huy N., et al.
Publicado: (2019)

Histidine-based copper tetrapeptides as enantioselective catalysts for aldol reactions
por: Sharifa Zaithun, Begum, et al.
Publicado: (2018)

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds
por: Mitchell, Wayne, et al.
Publicado: (2022)

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides
por: Kwan, Jason C., et al.
Publicado: (2010)

β(2)-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP
por: Tymecka, Dagmara, et al.
Publicado: (2020)

Spectroscopic and Theoretical Studies of Hg(II) Complexation with Some Dicysteinyl Tetrapeptides
por: Springfield, Elliot, et al.
Publicado: (2021)

Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping
por: Mukherjee, Meghomukta, et al.
Publicado: (2021)

Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration
por: Nhu, Nguyen Thanh, et al.
Publicado: (2022)

Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE
por: Mitkevich, Vladimir A, et al.
Publicado: (2023)

The reactivity and conformational control of cyclic tetrapeptides derived from aziridine-containing amino acids
por: Chung, Benjamin K. W., et al.
Publicado: (2016)

One-Pot Isomerization–Cross Metathesis–Reduction (ICMR) Synthesis of Lipophilic Tetrapeptides
por: Jida, Mouhamad, et al.
Publicado: (2014)

Anti-Inflammatory Activity of a Cyclic Tetrapeptide in Mouse and Human Experimental Models
por: Zimecki, Michał, et al.
Publicado: (2020)

Impact of Tetrapeptide-FSEY on Oxidative and Physical Stability of Hazelnut Oil-In-Water Emulsion
por: Shi, Chenshan, et al.
Publicado: (2021)

Investigation of the Effect of Turn Residues on Tetrapeptide Aldol Catalysts with β-Turn Propensity
por: Liu, Albert Y., et al.
Publicado: (2022)

Synthesis, In Silico Logp Study, and In Vitro Analgesic Activity of Analogs of Tetrapeptide FELL
por: Borisova, Boryana, et al.
Publicado: (2023)

Intramolecular Modulation of Serine Protease Inhibitor Activity in a Marine Cyanobacterium with Antifeedant Properties
por: Matthew, Susan, et al.
Publicado: (2010)

The α(1)-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa
por: Dutt, Mriga, et al.
Publicado: (2019)

Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface
por: Sianati, Setareh, et al.
Publicado: (2021)

Discovery and Anti-Inflammatory Activity of a Cyanobacterial Fatty Acid Targeting the Keap1/Nrf2 Pathway
por: Al-Awadhi, Fatma H., et al.
Publicado: (2023)

A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum
por: Ali, Hazrat, et al.
Publicado: (2014)

Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis
Publicado: (1976)

The tetrapeptide core of the carrier peptide Xentry is cell-penetrating: novel activatable forms of Xentry
por: Montrose, Kristopher, et al.
Publicado: (2014)

Antitumor and Antimicrobial Activity of Some Cyclic Tetrapeptides and Tripeptides Derived from Marine Bacteria
por: Chakraborty, Subrata, et al.
Publicado: (2015)

Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro
por: Akhmadishina, Rezeda A., et al.
Publicado: (2018)

Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors
por: Scala, Maria Carmina, et al.
Publicado: (2017)

The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
por: Exconde, Patrick M., et al.
Publicado: (2023)

Diversity, Biosynthesis and Bioactivity of Aeruginosins, a Family of Cyanobacteria-Derived Nonribosomal Linear Tetrapeptides
por: Liu, Jiameng, et al.
Publicado: (2023)

Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration
por: Sadeghi, Mahsa, et al.
Publicado: (2013)

Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity
por: Lizarme-Salas, Yuvixza, et al.
Publicado: (2020)

Interaction With the Lipid Membrane Influences Fentanyl Pharmacology
por: Sutcliffe, Katy J., et al.
Publicado: (2022)

Amino Acid Sequence in Constitutionally Isomeric Tetrapeptide Amphiphiles Dictates Architecture of One-Dimensional Nanostructures
por: Cui, Honggang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_bvlvptrrqmvs0ouc5ncp58gk5n