Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling

Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their Myc levels, which correlates with refractoriness to therapy and poor prog...

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Detalles Bibliográficos
Autores principales: Kreuzaler, Peter, Clarke, Matthew A., Brown, Elizabeth J., Wilson, Catherine H., Kortlever, Roderik M., Piterman, Nir, Littlewood, Trevor, Evan, Gerard I., Fisher, Jasmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825310/
https://www.ncbi.nlm.nih.gov/pubmed/31611367
http://dx.doi.org/10.1073/pnas.1903485116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825310/
https://www.ncbi.nlm.nih.gov/pubmed/31611367
http://dx.doi.org/10.1073/pnas.1903485116

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