The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu(5) receptor case study

Stabilizing unique receptor conformations, allosteric modulators of G-protein coupled receptors (GPCRs) might open novel treatment options due to their new pharmacological action, their enhanced specificity and selectivity in both binding and signaling. Ligand binding occurs at intrahelical alloster...

Descripción completa

Detalles Bibliográficos
Autores principales: Orgován, Zoltán, Ferenczy, György G., Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825653/
https://www.ncbi.nlm.nih.gov/pubmed/31542869
http://dx.doi.org/10.1007/s10822-019-00224-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825653/
https://www.ncbi.nlm.nih.gov/pubmed/31542869
http://dx.doi.org/10.1007/s10822-019-00224-w

Ejemplares similares