Docking‐based approach for identification of mutations that disrupt binding between Bcl‐2 and Bax proteins: Inducing apoptosis in cancer cells

BACKGROUND: Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl‐2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl‐2 family. Exome sequencing has identified Bcl‐2 and Bax missense mutat...

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Detalles Bibliográficos
Autores principales: Raghav, Pawan Kumar, Kumar, Rajesh, Kumar, Vinod, Raghava, Gajendra P. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825947/
https://www.ncbi.nlm.nih.gov/pubmed/31490001
http://dx.doi.org/10.1002/mgg3.910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825947/
https://www.ncbi.nlm.nih.gov/pubmed/31490001
http://dx.doi.org/10.1002/mgg3.910

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