USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells

BRCA1, a multifunctional protein with an important role in DNA double‐strand break repair by homologous recombination (HR), is subjected to ubiquitin‐dependent degradation. To date, several E3 ubiquitin ligases have been identified to govern BRCA1 stability, but the deubiquitinase that counteracts i...

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Detalles Bibliográficos
Autores principales: Lu, Qin, Zhang, Fang‐Lin, Lu, Da‐Yun, Shao, Zhi‐Ming, Li, Da-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825982/
https://www.ncbi.nlm.nih.gov/pubmed/31512408
http://dx.doi.org/10.1002/cam4.2528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825982/
https://www.ncbi.nlm.nih.gov/pubmed/31512408
http://dx.doi.org/10.1002/cam4.2528

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