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Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate

Cleft palate (CP) is one of the most common congenital craniofacial anomalies in humans and can be caused by either single or multiple genetic and environmental factor(s). With respect to environmental factors, excessive intake of vitamin A during early pregnancy is associated with increased inciden...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Kurosaka, Hiroshi, Kikuchi, Masataka, Nakaya, Akihiro, Trainor, Paul A., Yamashiro, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826016/
https://www.ncbi.nlm.nih.gov/pubmed/31591086
http://dx.doi.org/10.1242/dmm.040279