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Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice

The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and is associated with increased HIV-1 acquisitio...

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Detalles Bibliográficos
Autores principales: Wessels, Jocelyn M., Lajoie, Julie, Cooper, Maeve I. J. Hay, Omollo, Kenneth, Felker, Allison M., Vitali, Danielle, Dupont, Haley A., Nguyen, Philip V., Mueller, Kristen, Vahedi, Fatemeh, Kimani, Joshua, Oyugi, Julius, Cheruiyot, Juliana, Mungai, John N., Deshiere, Alexandre, Tremblay, Michel J., Mazzulli, Tony, Stearns, Jennifer C., Ashkar, Ali A., Fowke, Keith R., Surette, Michael G., Kaushic, Charu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826019/
https://www.ncbi.nlm.nih.gov/pubmed/31537512
http://dx.doi.org/10.1242/dmm.039669