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Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited for therapeutic treatment, as decreasing dietary methionine sele...

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Detalles Bibliográficos
Autores principales: Parkhitko, Andrey A., Jouandin, Patrick, Mohr, Stephanie E., Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826121/
https://www.ncbi.nlm.nih.gov/pubmed/31460700
http://dx.doi.org/10.1111/acel.13034