Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

The accumulation of mitochondrial DNA (mtDNA) mutations is a suspected driver of aging and age‐related diseases, but forestalling these changes has been a major challenge. One of the best‐studied models is the prematurely aging mtDNA mutator mouse, which carries a homozygous knock‐in of a proofreadi...

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Detalles Bibliográficos
Autores principales: Ross, Jaime M., Coppotelli, Giuseppe, Branca, Rui M., Kim, Kyung M., Lehtiö, Janne, Sinclair, David A., Olson, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826127/
https://www.ncbi.nlm.nih.gov/pubmed/31489782
http://dx.doi.org/10.1111/acel.13029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826127/
https://www.ncbi.nlm.nih.gov/pubmed/31489782
http://dx.doi.org/10.1111/acel.13029

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