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Reversal of epigenetic aging and immunosenescent trends in humans

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved r...

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Autores principales: Fahy, Gregory M., Brooke, Robert T., Watson, James P., Good, Zinaida, Vasanawala, Shreyas S., Maecker, Holden, Leipold, Michael D., Lin, David T. S., Kobor, Michael S., Horvath, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/
https://www.ncbi.nlm.nih.gov/pubmed/31496122
http://dx.doi.org/10.1111/acel.13028
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author Fahy, Gregory M.
Brooke, Robert T.
Watson, James P.
Good, Zinaida
Vasanawala, Shreyas S.
Maecker, Holden
Leipold, Michael D.
Lin, David T. S.
Kobor, Michael S.
Horvath, Steve
author_facet Fahy, Gregory M.
Brooke, Robert T.
Watson, James P.
Good, Zinaida
Vasanawala, Shreyas S.
Maecker, Holden
Leipold, Michael D.
Lin, David T. S.
Kobor, Michael S.
Horvath, Steve
author_sort Fahy, Gregory M.
collection PubMed
description Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age‐related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 year of treatment (−2.5‐year change compared to no treatment at the end of the study). The rate of epigenetic aging reversal relative to chronological age accelerated from −1.6 year/year from 0–9 month to −6.5 year/year from 9–12 month. The GrimAge predictor of human morbidity and mortality showed a 2‐year decrease in epigenetic vs. chronological age that persisted six months after discontinuing treatment. This is to our knowledge the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by means of a currently accessible aging intervention.
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spelling pubmed-68261382019-12-01 Reversal of epigenetic aging and immunosenescent trends in humans Fahy, Gregory M. Brooke, Robert T. Watson, James P. Good, Zinaida Vasanawala, Shreyas S. Maecker, Holden Leipold, Michael D. Lin, David T. S. Kobor, Michael S. Horvath, Steve Aging Cell Original Articles Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age‐related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 year of treatment (−2.5‐year change compared to no treatment at the end of the study). The rate of epigenetic aging reversal relative to chronological age accelerated from −1.6 year/year from 0–9 month to −6.5 year/year from 9–12 month. The GrimAge predictor of human morbidity and mortality showed a 2‐year decrease in epigenetic vs. chronological age that persisted six months after discontinuing treatment. This is to our knowledge the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by means of a currently accessible aging intervention. John Wiley and Sons Inc. 2019-09-08 2019-12 /pmc/articles/PMC6826138/ /pubmed/31496122 http://dx.doi.org/10.1111/acel.13028 Text en © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Fahy, Gregory M.
Brooke, Robert T.
Watson, James P.
Good, Zinaida
Vasanawala, Shreyas S.
Maecker, Holden
Leipold, Michael D.
Lin, David T. S.
Kobor, Michael S.
Horvath, Steve
Reversal of epigenetic aging and immunosenescent trends in humans
title Reversal of epigenetic aging and immunosenescent trends in humans
title_full Reversal of epigenetic aging and immunosenescent trends in humans
title_fullStr Reversal of epigenetic aging and immunosenescent trends in humans
title_full_unstemmed Reversal of epigenetic aging and immunosenescent trends in humans
title_short Reversal of epigenetic aging and immunosenescent trends in humans
title_sort reversal of epigenetic aging and immunosenescent trends in humans
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/
https://www.ncbi.nlm.nih.gov/pubmed/31496122
http://dx.doi.org/10.1111/acel.13028
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