Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts

Somatic mutations are critical for cancer development and may play a role in age‐related functional decline. Here, we used deep sequencing to analyze the prevalence of somatic mutations during in vitro cell aging. Primary dermal fibroblasts from healthy subjects of young and advanced age, from Hutch...

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Detalles Bibliográficos
Autores principales: Narisu, Narisu, Rothwell, Rebecca, Vrtačnik, Peter, Rodríguez, Sofía, Didion, John, Zöllner, Sebastian, Erdos, Michael R., Collins, Francis S., Eriksson, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826141/
https://www.ncbi.nlm.nih.gov/pubmed/31385397
http://dx.doi.org/10.1111/acel.13010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826141/
https://www.ncbi.nlm.nih.gov/pubmed/31385397
http://dx.doi.org/10.1111/acel.13010

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