Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline

Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice expressing p38α‐lox and CamkII‐Cre alleles (p38α∆...

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Detalles Bibliográficos
Autores principales: Moreno‐Cugnon, Leire, Revuelta, Miren, Arrizabalaga, Olatz, Colie, Sandra, Moreno‐Valladares, Manuel, Jimenez‐Blasco, Daniel, Gil‐Bea, Francisco, Llarena, Irantzu, Bolaños, Juan Pedro, Nebreda, Angel R., Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826142/
https://www.ncbi.nlm.nih.gov/pubmed/31560167
http://dx.doi.org/10.1111/acel.13044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826142/
https://www.ncbi.nlm.nih.gov/pubmed/31560167
http://dx.doi.org/10.1111/acel.13044

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